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KMID : 0614619950270040457
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Korean Journal of Gastroenterology
1995 Volume.27 No. 4 p.457 ~ p.462
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Effects of Ursodeoxychlic acid9UDCA) on Dissolution of Radiolucent Gallbladder Stones
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김명환
유병무/송일한/박선미/김석균/최호순/이성구/서동진/민영일
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Abstract
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Background/Aims:
@EN The gallstone composition among Asians is known to be different from that of Caucasians. Thus, we tested the hypothesis that the dissolution rate of radiolucent gallbladder stones by oral bile acid may be different between Koreans and
Caucasians.
@ES Methods:
@EN Sixty patients with radiolucent gallbladder stones were treated with ursodeoxycholic acid (10mg/kg) for 6 months. Abdominal ultrasonogram was measured monthly for evaluation of complete dissolution.
@ES Results:
@EN Complete dissolution of gallstones occurred in 7 patients (12%) , especially in the patients with gallstone diameter≤Smm. However, symptoms of biliary colic and dyspepsia were relieved during ursodeoxycholic acid treatment in 30 (75%) out of
40
patients, without relationship to complete dissolution.
@ES Conclusion:
@EN The complete dissolution rate of radiolucent gallbladder stones by ursodeoxycholic acid is lower than that of Caucasians. This may be related to the mixing of calcium bilirubinate and cholesterol stones in the radiolucent stones. Calcium
bilirubinate stones of the gallbladder origin are not rare in Koreans and such stones commonly show radiolucency by simple abdominal x-ray film. (Korean J Gastroenterol 1995; 27: 457-462)
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